KRT13, FAIM2 and CYP2W1 mRNA expression in oral squamous cell carcinoma patients with risk habits.

Abstract

BACKGROUND:

Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways.

MATERIALS AND METHODS:

cDNAs from 41 OSCC samples with and without risk habits were included in this study. Quantitative real-time PCR was used to analyze KRT13, FAIM2 and CYP2W1 in OSCC. The housekeeping gene (GAPDH) was used as an endogenous control.

RESULTS:

Of the 41 OSCC samples, KRT13 was down-regulated in 40 samples (97.6%), while FAIM2 and CYP2W1 were down-regulated in 61.0% and 48.8%, respectively. Overall, there were no associations between KRT13, FAIM2 and CYP2W1 expression with risk habits, selected socio-demographic and clinico-pathological parameters and patient survival.

CONCLUSIONS:

Although this study was unable to show significance, there were some tendencies in the associations of KRT13, FAIM2 and CYP2W1 expression in OSCC with selected clinic-pathological parameters and survival.

• Authors: Firstine Kelsi Hartanto, Lee Peng Karen-Ng, Vui King Vincent-Chong, Siti Mazlipah Ismail, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Rosnah Binti Zain
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 3 Pg. 953-8 ( 2015) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25735388 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Apoptosis Regulatory Proteins
• Biomarkers, Tumor
• FAIM2 protein, human
• KRT13 protein, human
• Keratin-13
• Membrane Proteins
• RNA, Messenger
• Cytochrome P-450 Enzyme System
• CYP2W1 protein, human
• Cytochrome P450 Family 2

Topics

• Adult
• Apoptosis Regulatory Proteins (genetics)
• Biomarkers, Tumor (genetics)
• Carcinoma, Squamous Cell (genetics, mortality, pathology)
• Cross-Sectional Studies
• Cytochrome P-450 Enzyme System (genetics)
• Cytochrome P450 Family 2
• Female
• Follow-Up Studies
• Humans
• Keratin-13 (genetics)
• Lymphatic Metastasis
• Male
• Membrane Proteins (genetics)
• Mouth Neoplasms (genetics, mortality, pathology)
• Neoplasm Staging
• Prognosis
• RNA, Messenger (genetics)
• Real-Time Polymerase Chain Reaction
• Risk Factors
• Survival Rate