Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer.

Abstract

Chemoresistance is the most common cause of chemotherapy failure during breast cancer (BCA) treatment. It is generally known that the mechanisms of chemoresistance in tumors involve multiple genes and multiple signaling pathways,; if appropriate drugs are used to regulate the mechanisms at the gene level, it should be possible to effectively reverse chemoresistance in BCA cells. It has been confirmed that chemoresistance in BCA cells could be reversed by ginsenoside Rh2 (G-Rh2). Preliminary studies of our group identified some drug- resistance specific miRNA. Accordingly, we proposed that G-Rh2 could mediate drug-resistance specific miRNA and corresponding target genes through the gene regulatory network; this could cut off the drug-resistance process in tumors and enhance treatment effects. G-Rh2 and breast cancer cells were used in our study. Through pharmaceutical interventions, we could explore how G-Rh2 could inhibit chemotherapy resistance in BCA, and analyze its impact on related miRNA and target genes. Finally, we will reveal the anti-resistance molecular mechanisms of G-Rh2 from a different angle in miRNA-mediated chemoresistance signals among cells.

• Authors: Xu Wen, He-Da Zhang, Li Zhao, Yu-Feng Yao, Jian-Hua Zhao, Jin-Hai Tang
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 3 Pg. 1105-9 ( 2015) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25735339 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Ginsenosides
• MicroRNAs
• RNA, Messenger
• ginsenoside Rh2

Topics

• Apoptosis
• Blotting, Western
• Breast Neoplasms (drug therapy, genetics, pathology)
• Cell Proliferation
• Drug Resistance, Neoplasm (genetics)
• Drugs, Chinese Herbal (chemistry)
• Female
• Gene Expression Regulation, Neoplastic (drug effects)
• Ginsenosides (pharmacology)
• Humans
• MicroRNAs (genetics)
• Oligonucleotide Array Sequence Analysis
• RNA, Messenger (genetics)
• Real-Time Polymerase Chain Reaction
• Reverse Transcriptase Polymerase Chain Reaction
• Signal Transduction (drug effects)
• Tumor Cells, Cultured