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Role of sGC-dependent NO signalling and myocardial infarction risk.

Abstract
The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.
AuthorsJana Wobst, Thorsten Kessler, Tan An Dang, Jeanette Erdmann, Heribert Schunkert
JournalJournal of molecular medicine (Berlin, Germany) (J Mol Med (Berl)) Vol. 93 Issue 4 Pg. 383-94 (Apr 2015) ISSN: 1432-1440 [Electronic] Germany
PMID25733135 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Receptors, Cytoplasmic and Nuclear
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Guanylate Cyclase
  • Soluble Guanylyl Cyclase
  • Cyclic GMP
Topics
  • Animals
  • Cyclic GMP (metabolism)
  • Cyclic Nucleotide Phosphodiesterases, Type 5 (genetics, metabolism)
  • Guanylate Cyclase (genetics, metabolism)
  • Humans
  • Mutation
  • Myocardial Infarction (drug therapy, genetics, metabolism)
  • Nitric Oxide (metabolism)
  • Nitric Oxide Synthase Type III (genetics, metabolism)
  • Polymorphism, Genetic
  • Receptors, Cytoplasmic and Nuclear (genetics, metabolism)
  • Signal Transduction
  • Soluble Guanylyl Cyclase

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