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[A case of locally advanced pancreatic cancer successfully resected after gemcitabine+S-1 therapy].

Abstract
A 6 1-year-old man who was admitted to our hospital because of obstructive jaundice. He was diagnosed with locally advanced cancer of the pancreatic head on computed tomography. Gemcitabine (1,000 mg/m² on days 8 and 15, every 21 days) + S-1 (6 0 mg/m² on day 1-15, every 21 days) chemotherapy was administered because the tumor had invaded the common hepatic artery and portal vein. The tumor was reduced following 9 months of chemotherapy. Thus, subtotal stomach- preserving pancreaticoduodenectomy (SSPPD)was performed. The histopathological findings indicated no invasion of the cancer into the surrounding tissues. No recurrence has occurred 7 months after surgery. Neoadjuvant chemotherapy is important for effective treatment of locally advanced pancreatic cancer.
AuthorsMakoto Moriyama, Shigeaki Sawada, Koshi Matsui, Isaku Yoshioka, Kazuto Shibuya, Soshi Osawa, Toru Yoshida, Takuya Nagata, Kazuhiro Tsukada
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 12 Pg. 2187-9 (Nov 2014) ISSN: 0385-0684 [Print] Japan
PMID25731465 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Drug Combinations
  • Deoxycytidine
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Gemcitabine
Topics
  • Adenocarcinoma (drug therapy, surgery)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Drug Combinations
  • Humans
  • Male
  • Middle Aged
  • Neoadjuvant Therapy
  • Oxonic Acid (administration & dosage)
  • Pancreatic Neoplasms (drug therapy, pathology, surgery)
  • Pancreaticoduodenectomy
  • Tegafur (administration & dosage)
  • Treatment Outcome
  • Gemcitabine

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