[Two cases of neuroendocrine tumors of the pancreas with multiple liver metastases treated by use of degradable starch microspheres and octreotide].

Abstract

The first case involved a 38-year-old man who received a pancreaticoduodenectomy and hepatectomy for a pancreatic neuroendocrine tumor (pNET) with multiple liver metastases. A recurrent tumor was detected in his liver 3 months after surgery. The second case involved a 61-year-old woman who received a distal pancreatectomy for a pNET. Multiple liver metastases were detected 29 months later. Both patients received a combined therapy consisting of trans-catheter arterial chemoembolization (TACE) with degradable starch microspheres (DSM) and octreotide. The combined therapy prolonged progression-free survival in both cases. Although only 2 cases were evaluated in this study, multimodal treatment consisting of TACE with DSM and octreotide effectively controlled liver metastasis of pNET in both cases.

• Authors: Wataru Goto, Sadatoshi Shimizu, Masaya Kotsuka, Masayuki Sakae, Akishige Kanazawa, Tadashi Tsukamoto, Yoshito Yamashita, Yukio Nishiguchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 12 Pg. 2139-41 (Nov 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25731449 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• degradable starch microspheres
• Starch
• Octreotide

Topics

• Adult
• Chemoembolization, Therapeutic
• Embolization, Therapeutic
• Female
• Humans
• Liver Neoplasms (secondary, therapy)
• Male
• Middle Aged
• Neuroendocrine Tumors (secondary, therapy)
• Octreotide (administration & dosage)
• Pancreatic Neoplasms (pathology, therapy)
• Starch (administration & dosage)