Abstract | BACKGROUND: METHODS: MCF-7 and MDA-MB-231 breast cancer cells were treated with SBHA, Bortezomib, and MG-132 alone or in combination for 72 h. Cell proliferation, colony formation, apoptosis and gene expression changes were examined. RESULTS: SBHA, Bortezomib, and MG-132 alone significantly inhibited the proliferation and colony formation and induced apoptosis in MCF-7 and MDA-MB-231 cells. Combined treatment showed a good synergistic antitumour effect against breast cancer cells. The p53 protein level was significantly elevated by combined treatment with SBHA and proteasome inhibitors. Moreover, combined treatment increased the expression of Bax, Bcl-xS, and Bak and decreased the expression of Bcl-2. Combination of SBHA with proteasome inhibitors causes synergistic anticancer effects on breast cancer cells. The potential molecular mechanism may involve induction of p53 and modulation of the Bcl-2 family proteins. CONCLUSION:
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Authors | Xinmiao Yang, Zeliang Shi, Ning Zhang, Zhouluo Ou, Shen Fu, Xichun Hu, Zhenzhou Shen |
Journal | Cancer cell international
(Cancer Cell Int)
Vol. 14
Pg. 107
( 2014)
ISSN: 1475-2867 [Print] England |
PMID | 25729327
(Publication Type: Journal Article)
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