Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives.

Abstract

Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.

• Authors: Irene Santos-Pardo, Roger Villuendas, Iñaki Salvador-Corres, Melania Martínez-Morillo, Alejandro Olivé, Antoni Bayes-Genis
• Journal: International journal of cardiology (Int J Cardiol) Vol. 184 Pg. 244-250 (Apr 01 2015) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 25725306 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014. Published by Elsevier Ireland Ltd.

Chemical References

• Autoantibodies
• Biomarkers
• Ribonucleoproteins
• SS-A antigen

Topics

• Arrhythmias, Cardiac (blood, diagnosis, immunology)
• Autoantibodies (blood)
• Biomarkers (blood)
• Case-Control Studies
• Forecasting
• Humans
• Retrospective Studies
• Ribonucleoproteins (blood)