Microcyclosporella mali: a novel fungal keratitis in a post-penetrating keratoplasty patient.

Abstract

An 86-year-old woman underwent penetrating keratoplasty for pseudophakic bullous keratopathy and presented with an acute corneal ulcer thereafter. Examination demonstrated a fluffy white infiltrate and epithelial defect with subsequent endothelial plaque formation and anterior chamber inflammation. The ulcer was cultured, and fortified topical vancomycin and tobramycin were initiated but failed to significantly improve the clinical course. Cultures were ultimately positive for fungus Microcyclosporella mali that responded well to topical natamycin with stabilisation of the ulcer after 6 weeks of topical therapy. This is the first reported case of fungal keratitis due to M. mali.

• Authors: Neil Vyas, Saba Al-Hashimi, Wuqaas Munir
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2015 (Feb 27 2015) ISSN: 1757-790X [Electronic] England
• PMID: 25725025 (Publication Type: Case Reports, Journal Article)
• Copyright: 2015 BMJ Publishing Group Ltd.

Chemical References

• Antifungal Agents
• Natamycin

Topics

• Aged, 80 and over
• Antifungal Agents (therapeutic use)
• Corneal Ulcer (diagnosis, drug therapy, microbiology)
• Eye Infections, Fungal (diagnosis, drug therapy, microbiology)
• Female
• Humans
• Keratoplasty, Penetrating
• Natamycin (therapeutic use)
• Postoperative Complications (diagnosis, drug therapy, microbiology)
• Treatment Outcome