[Cesarean scar ectopic pregnancies: combined modality therapies with uterine artery embolization before surgical procedure].

Abstract

OBJECTIVES:

To offer a therapeutic management of cesarean scar pregnancies (GSC) in the first trimester of pregnancy with a first approach by uterine artery embolization (UAE) PATIENTS AND METHODS: This study describes seven cases of GSC diagnosed between 2009 and 2013 in the clinic of the University Hospital of the Hospital of Croix-Rousse. We present the symptoms and how imagery has led to the diagnosis and the therapeutic management conducted.

RESULTS:

The mean gestational age at diagnosis was 9 weeks gestation. There were ongoing pregnancies with cardiac activity present for each patient. An additional MRI was performed in five patients. Five patients were treated with methotrexate injection, two patients received the Mifegyne. All patients then received a selective uterine artery embolization. Finally within 48hours, suction curettage was performed in 6 patients. A patient at 13 WA+1 required a subtotal hysterectomy for placenta accreta. Intra-operative complications were represented by a bladder injury, two bleeding of 1000mL in patients at 13 WA+1 and 12 WA. For the 6 cases of GSC with a gestational age less than 10 WA, average blood loss was less than 500mL. Three patients underwent resection of scar isthmocele confirmed by EVAC. An intrauterine pregnancy was carried to term after care.

DISCUSSION AND CONCLUSION:

Cesarean scar pregnancies is a diagnostic and therapeutic challenge, which should be diagnosed as early as soon as possible with care in a medical facility with a uterine artery embolization technical platform. Our protocol combining Mifegyne and methotrexate for termination of pregnancy and uterine artery embolization (UAE) followed by curettage for evacuation of pregnancy allows conservative treatment while minimizing the risk of bleeding (for GSC diagnosed before 10 WA).

• Authors: J Le Gall, A Fichez, G Lamblin, C A Philip, C Huissoud
• Journal: Gynecologie, obstetrique & fertilite (Gynecol Obstet Fertil) Vol. 43 Issue 3 Pg. 191-9 (Mar 2015) ISSN: 1769-6682 [Electronic] France
• Vernacular Title: Grossesse sur cicatrice de césarienne : traitement combiné avec embolisation des artères utérines avant procédure chirurgicale.
• PMID: 25724449 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Abortifacient Agents, Nonsteroidal
• Abortifacient Agents, Steroidal
• Mifepristone
• Methotrexate

Topics

• Abortifacient Agents, Nonsteroidal
• Abortifacient Agents, Steroidal
• Blood Loss, Surgical
• Cesarean Section (adverse effects)
• Cicatrix (etiology)
• Combined Modality Therapy
• Curettage
• Female
• Gestational Age
• Humans
• Hysterectomy
• Methotrexate (administration & dosage)
• Mifepristone (administration & dosage)
• Pregnancy
• Pregnancy Trimester, First
• Pregnancy, Ectopic (diagnosis, diagnostic imaging, surgery, therapy)
• Uterine Artery Embolization (adverse effects, methods)