Hyponatremia, defined as a serum
sodium concentration <135 mEq/L, represents the most frequent
electrolyte disorder in older hospitalized patients. Early recognition of
hyponatremia is mandatory, since it represents an independent risk factor that increases hospital mortality by 40 %. Delayed correction of
hyponatremia may worsen
brain edema, resulting in different degrees of neural damage. However, an overly rapid correction of serum
sodium levels can lead to osmotic
demyelination syndrome (ODS), a dreadful neurological picture. In recent years,
hyponatremia and ODS have received growing attention both in terms of clinical management and pathophysiology, leading to the discovery of new drugs and treatment algorithms. In this review, we recapitulate the pathogenetic background, clinical manifestations, and treatment guidelines of
hyponatremia, focusing on the neurological alterations. Neurological symptoms may be neglected when they manifest as early signs of mild
hyponatremia, while brain damage can irremediably affect patients' conditions in the context of ODS.