Abstract | BACKGROUND: MATERIALS AND METHODS: A systematic search of ClinicalTrials.gov, the Cochrane Library database, EMBASE, MEDLINE, Web of Science, and the World Health Organization trial registry, plus manual searches of gray literature, was undertaken in April 2013. Two reviewers independently extracted the data with a predefined data extraction form. RevMan 5 software was used to synthesize data and calculate the risk ratio for mortality with the 95% confidence interval. For the Glasgow Outcome Scale and posttreatment Glasgow Coma Scale data, the weighted mean difference was calculated with the 95% confidence interval. RESULTS: A total of 8 randomized controlled trials with a total of 786 patients were included. Meta-analysis showed that there was no significant difference between the groups for mortality. The Glasgow Outcome Scale of the treatment group was higher than that of the control group, although the significance was borderline. The Glasgow Coma Scale score change posttreatment was significantly higher than that of the control. CONCLUSIONS:
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Authors | Wen Li, Yin-An Bai, Ya-Jun Li, Kai-Ge Liu, Mao-De Wang, Gang-Zhu Xu, Hong-Li Shang, Yan-Feng Li |
Journal | The Journal of craniofacial surgery
(J Craniofac Surg)
Vol. 26
Issue 2
Pg. 393-8
(Mar 2015)
ISSN: 1536-3732 [Electronic] United States |
PMID | 25723660
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Neuroprotective Agents
- Magnesium Sulfate
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Topics |
- Brain Injuries
(drug therapy)
- Cause of Death
- Glasgow Coma Scale
- Glasgow Outcome Scale
- Humans
- Magnesium Sulfate
(therapeutic use)
- Neuroprotective Agents
(therapeutic use)
- Survival Rate
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