Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.

Abstract

A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.

• Authors: Yunliang Xie, Yanbo Liu, Weigao Shen, Bo Zhang, Qun Liu
• Journal: Neural regeneration research (Neural Regen Res) Vol. 7 Issue 13 Pg. 1013-9 (May 05 2012) ISSN: 1673-5374 [Print] India
• PMID: 25722690 (Publication Type: Journal Article)