HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice.

Abstract
Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It was found that B16 melanoma tissues produce 5,6-dihydroxyindole-2-carboxylic acid and its two O-methyl derivatives, the latter of which are partly conjugated with sulphuric acid and then excreted. These indolic metabolites are referred to as total indoles. Both total indoles and 5-S-CD in melanoma and in urine correlated well with each other and reflected the tumour weight. Total indoles had a four-fold greater level of excretion than 5-S-CD, suggesting that the urinary excretion of total indoles is a quantitatively more significant marker of melanoma progression in this melanoma.
AuthorsS Ito, K Wakamatsu, S Inoue, K Fujita
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 69 Issue 5 Pg. 380-4 ( 1989) ISSN: 0001-5555 [Print] Sweden
PMID2572100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Indoles
  • Melanins
  • Cysteinyldopa
  • Dihydroxyphenylalanine
  • 5,6-dihydroxyindole
Topics
  • Animals
  • Cysteinyldopa (metabolism)
  • Dihydroxyphenylalanine (analogs & derivatives)
  • Indoles (metabolism, urine)
  • Melanins (metabolism)
  • Melanoma (metabolism, pathology, urine)
  • Mice
  • Mice, Inbred C57BL
  • Organ Size

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: