Abstract |
Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It was found that B16 melanoma tissues produce 5,6-dihydroxyindole-2-carboxylic acid and its two O-methyl derivatives, the latter of which are partly conjugated with sulphuric acid and then excreted. These indolic metabolites are referred to as total indoles. Both total indoles and 5-S-CD in melanoma and in urine correlated well with each other and reflected the tumour weight. Total indoles had a four-fold greater level of excretion than 5-S-CD, suggesting that the urinary excretion of total indoles is a quantitatively more significant marker of melanoma progression in this melanoma.
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Authors | S Ito, K Wakamatsu, S Inoue, K Fujita |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 69
Issue 5
Pg. 380-4
( 1989)
ISSN: 0001-5555 [Print] Sweden |
PMID | 2572100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- Melanins
- Cysteinyldopa
- Dihydroxyphenylalanine
- 5,6-dihydroxyindole
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Topics |
- Animals
- Cysteinyldopa
(metabolism)
- Dihydroxyphenylalanine
(analogs & derivatives)
- Indoles
(metabolism, urine)
- Melanins
(metabolism)
- Melanoma
(metabolism, pathology, urine)
- Mice
- Mice, Inbred C57BL
- Organ Size
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