Abstract | IMPORTANCE: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-blind, placebo-controlled clinical trial at an institutional referral center among a sample of individuals with rhinomegaly. INTERVENTIONS: Patients were randomized into 2 groups. In group 1, dexamethasone was intravenously injected before surgery. In group 2, normal saline solution was intravenously injected before surgery. MAIN OUTCOMES AND MEASURES: RESULTS: Forty-two patients participated in the study. Randomization by lottery resulted in 20 patients in group 1 and 22 patients in group 2. Group 1 showed lower rates of postoperative ecchymosis than group 2; the difference of 0.62 (P = .02) reflects less perceived ecchymosis when dexamethasone was administered. Group 1 also showed lower rates of postoperative edema than group 2; the difference of 0.68 (P = .01) reflects less perceived edema when dexamethasone was administered. CONCLUSIONS AND RELEVANCE: LEVEL OF EVIDENCE: 1.
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Authors | Denis S Valente, Niveo Steffen, Lauro A Carvalho, Giuliano B Borille, Rafaela K Zanella, Alexandre V Padoin |
Journal | JAMA facial plastic surgery
(JAMA Facial Plast Surg)
2015 May-Jun
Vol. 17
Issue 3
Pg. 169-73
ISSN: 2168-6092 [Electronic] United States |
PMID | 25719757
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glucocorticoids
- Placebos
- Dexamethasone
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Topics |
- Dexamethasone
(administration & dosage)
- Double-Blind Method
- Ecchymosis
(prevention & control)
- Edema
(prevention & control)
- Female
- Glucocorticoids
(administration & dosage)
- Humans
- Injections, Intravenous
- Intraoperative Care
- Male
- Placebos
- Postoperative Complications
(prevention & control)
- Rhinoplasty
- Treatment Outcome
- Young Adult
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