Abstract | BACKGROUND: Diplazium esculentum is the most commonly consumed edible fern throughout Asia and Oceania. Several studies have been performed so far to determine different functional properties of this plant, but there have been no reports on the anticholinesterase and nicotinamide adenine dinucleotide ( NADH) oxidase inhibitory activities of this plant. Therefore, the present study was conducted to determine the anticholinesterase and NADH oxidase inhibitory activities of 70% methanolic extract of D. esculentum. METHODS: RESULTS: The D. esculentum extract inhibited acetylcholinesterase and NADH oxidase in a dose-dependent manner, with IC50 values of 272.97±19.38 and 265.81±21.20 μg/mL, respectively. The extract also showed a potent DPPH radical scavenging activity with an IC50 value of 402.88±12.70 μg/mL. Moreover, the extract showed 27.41% and 33.22% of total antioxidant activities determined by FTC and TBA methods, respectively. CONCLUSIONS:
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Authors | Subhrajyoti Roy, Somit Dutta, Tapas Kumar Chaudhuri |
Journal | Journal of basic and clinical physiology and pharmacology
(J Basic Clin Physiol Pharmacol)
Vol. 26
Issue 4
Pg. 395-401
(Jul 2015)
ISSN: 2191-0286 [Electronic] Germany |
PMID | 25719308
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Cholinesterase Inhibitors
- Free Radical Scavengers
- Multienzyme Complexes
- Plant Extracts
- NADH oxidase
- NADH, NADPH Oxidoreductases
- alpha-Tocopherol
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Topics |
- Antioxidants
(pharmacology)
- Cholinesterase Inhibitors
(pharmacology)
- Dose-Response Relationship, Drug
- Free Radical Scavengers
(pharmacology)
- Inhibitory Concentration 50
- Multienzyme Complexes
(antagonists & inhibitors)
- NADH, NADPH Oxidoreductases
(antagonists & inhibitors)
- Plant Extracts
(pharmacology)
- Polypodiaceae
- alpha-Tocopherol
(pharmacology)
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