Oral isotretinoin as the most effective treatment in folliculitis decalvans: a retrospective comparison of different treatment regimens in 28 patients.

Abstract

BACKGROUND:

Folliculitis decalvans leads to scarring alopecia through inflammatory destruction of the hair follicle. Currently, antibiotics are most commonly used to treat this disease. However, treatment regimens with antibiotics feature a high relapse rate and encourage the development of resistant bacteria.

OBJECTIVE:

To evaluate the outcome of different treatment options for folliculitis decalvans.

METHODS:

Retrospective study to compare the efficacy of different treatment regimens in 28 patients with folliculitis decalvans.

RESULTS:

The success of treatment with clindamycin and rifampicin, clarithromycin, dapsone and isotretinoin was analysed. The evaluation of the combination of clindamycin and rifampicin showed the lowest success rate in achieving long-term remission, since 80% of the patients relapsed shortly after end of treatment. Clarithromycin and dapsone were more successful with long-term and stable remission rates of 33% and 43% respectively. Treatment with isotretinoin was the most successful oral treatment in our analysis with 90% of the patients experiencing stable remission during and up to two years after cessation of the treatment.

CONCLUSION:

The common use of antibiotics as first-line therapy in folliculitis decalvans needs to be re-evaluated critically and oral isotretinoin should be considered as valid treatment alternative.

• Authors: J K Tietze, M V Heppt, A von Preußen, U Wolf, T Ruzicka, H Wolff, E C Sattler
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 29 Issue 9 Pg. 1816-21 (Sep 2015) ISSN: 1468-3083 [Electronic] England
• PMID: 25712452 (Publication Type: Journal Article)
• Copyright: © 2015 European Academy of Dermatology and Venereology.

Chemical References

• Anti-Bacterial Agents
• Dermatologic Agents
• Clindamycin
• Isotretinoin
• Rifampin

Topics

• Administration, Oral
• Adult
• Anti-Bacterial Agents (administration & dosage)
• Clindamycin (administration & dosage)
• Dermatologic Agents (administration & dosage)
• Drug Therapy, Combination
• Female
• Folliculitis (diagnosis, drug therapy)
• Follow-Up Studies
• Humans
• Isotretinoin (administration & dosage)
• Male
• Middle Aged
• Retrospective Studies
• Rifampin (administration & dosage)
• Scalp Dermatoses (diagnosis, drug therapy)
• Treatment Outcome
• Young Adult