HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Surface ECG f Wave Analysis of Dofetilide Drug Effect in the Atrium.

AbstractINTRODUCTION:
The electrocardiogram (ECG) fibrillatory (f) wave characteristics in atrial fibrillation (AF) could provide important information regarding the efficacy of antiarrhythmic drug therapy.
METHODS AND RESULTS:
To measure the effects of dofetilide on the surface ECG f wave characteristics in patients with persistent AF, baseline and post-drug (2 hours after first dose and after multiple doses) ECGs in 31 patients with persistent AF admitted for dofetilide loading were evaluated. A QRST template subtraction algorithm was used to yield an atrial ECG. Fast Fourier transform analysis was performed to evaluate the maximum organizational index (OI), the dominant frequency (DF) in the lead with max OI, the median DF for all leads, and the vector magnitude f wave amplitude. Dofetilide reduced DF in the lead with the max OI (6.32 ± 0.98 Hz at baseline vs. 4.83 ± 0.63 Hz after final dose, P < 0.0001) and median DF (6.46 ± 0.87 Hz vs. 4.92 ± 0.62 Hz, P < 0.0001). Dofetilide also increased the maximum OI from 0.52 ± 0.11 at baseline to 0.59 ± 0.11 after final dose (P = 0.02). Of the 29 patients with long-term follow-up, the 22 (76%) with recurrent AF on dofetilide had a lower baseline DF in the lead with the max OI (6.01 ± 1.08 vs. 6.89 ± 0.46; P = 0.05). The change in DF after dofetilide did not correlate with the change in QTc interval.
CONCLUSIONS:
The standard ECG can be used to assess atrial rate in AF. This may be useful to assess antiarrhythmic drug effects for treatment of AF.
AuthorsViraj P Raygor, Jason Ng, Jeffrey J Goldberger
JournalJournal of cardiovascular electrophysiology (J Cardiovasc Electrophysiol) Vol. 26 Issue 6 Pg. 644-8 (Jun 2015) ISSN: 1540-8167 [Electronic] United States
PMID25711372 (Publication Type: Journal Article)
Copyright© 2015 Wiley Periodicals, Inc.
Chemical References
  • Anti-Arrhythmia Agents
  • Phenethylamines
  • Sulfonamides
  • dofetilide
Topics
  • Aged
  • Anti-Arrhythmia Agents (therapeutic use)
  • Atrial Fibrillation (drug therapy, physiopathology)
  • Electrocardiography
  • Female
  • Fourier Analysis
  • Heart Atria (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Phenethylamines (therapeutic use)
  • Retrospective Studies
  • Sulfonamides (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: