Abstract | PURPOSE: METHODS: This interventional case series included patients with MG injury suffering from severe dry eye despite receiving artificial tears and punctal plugs. Patients were administered tCsA 0.05% twice daily for 3 months. Severity of the condition was evaluated by measuring tear osmolarity, ocular surface disease index (OSDI), tear break-up time (TBUT), and Schirmer's test at baseline and at the end of study. RESULTS: A total of 34 patients with chronic MG injury and mean age of 47.1 ± 6.5 years were studied. Compared to baseline values, tear osmolarity (301.7 ± 11.5 vs. 286.3 ± 7.9 mOsmol/L, P < 0.001) and OSDI (47.5 ± 7.2 vs. 42.7 ± 7.1, P < 0.001) were significantly improved. Likewise, Schirmer's test (4.6 ± 1.3 vs. 5 ± 1.3 mm, P < 0.001) and TBUT (1.9 ± 1.4 vs. 2.7 ± 1.5 s, P < 0.001) also significantly recovered at the end of the study. CONCLUSION:
TCsA 0.05% reduces tear osmolarity and improves dry eye symptoms and can serve as an efficacious treatment for ocular complications in patients with chronic MG injury.
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Authors | Khosrow Jadidi, Yunes Panahi, Ali Ebrahimi, Mostafa Mafi, Farhad Nejat, Amirhossein Sahebkar |
Journal | Journal of ophthalmic & vision research
(J Ophthalmic Vis Res)
2014 Oct-Dec
Vol. 9
Issue 4
Pg. 417-22
ISSN: 2008-2010 [Print] United Arab Emirates |
PMID | 25709764
(Publication Type: Journal Article)
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