Antihypoxic activity of cycloprolylglycine analogs.

Abstract

We studied antihypoxic activity of analogs of endogenous cyclic dipeptide cycloprolylglycine in a mouse model of normobaric hypoxia with hypercapnia and found that antixypoxic effect depends on the structure of the substance. It was shown that different pharmacophores are responsible for the antihypoxic, nootropic, and anxiolytic effects of cycloprolylglycine.

• Authors: K N Kolyasnikova, G A Nazarova, T A Gudasheva, T A Voronina, S B Seredenin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 158 Issue 4 Pg. 458-60 (Feb 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 25708325 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Nootropic Agents
• Peptides, Cyclic
• cyclo(prolylglycyl)

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Hypercapnia (drug therapy)
• Hypoxia (drug therapy)
• Mice
• Molecular Structure
• Nootropic Agents (pharmacology)
• Peptides, Cyclic (chemistry, pharmacology)
• Statistics, Nonparametric