Combination treatment with whole body vibration and a kidney-tonifying herbal Fufang prevent osteoporosis in ovariectomized rats.

Abstract

OBJECTIVE:

To assess the ability of whole body vibration (WBV) with the kidney-tonifying herbal Fufang (Bushen Zhuanggu Granules, BZG) to prevent osteoporosis in ovariectomized rats.

METHODS:

Fifty 6-month-old female Sprague Dawley rats were divided into five groups: sham-operated (SHAM), ovariectomized (OVX), OVX with WBV (OVX + WBV), OVX with BZG (OVX + BZG), OVX with both WBV and BZG (OVX + WBV + BZG). The SHAM group received normal saline. After 12 weeks of treatment, the rats were killed, their serum concentrations of osteopontin (OPN), receptor activator of nuclear factor kappa-B ligand RANKL and bone turnover markers assayed and bone mineral density (BMD), histomorphometry and bone strength evaluated.

RESULTS:

Concentrations of OPN were significantly lower in the SHAM, OVX + WBV and OVX + WBV + BZG groups at 12 weeks, whereas concentrations of RANKL had decreased significantly in the SHAM, OVX + WBV, OVX + BZG and OVX + WBV + BZG groups. In the OVX + WBV, OVX + BZG and OVX + WBV + BZG groups the amount of bone turnover had been significantly antagonized. Compared with OVX group, BMD, % trabecular area (Tb.Ar), number of trabeculae (Tb.N) and assessed biomechanical variables were higher in OVX+WBV group, whereas and BMD, %Tb.Ar, Tb.N, maximal load and yield load were higher in the OVX + BZG group. All tested indices were significantly lower in the OVX + WBV and OVX + BZG groups than in the OVX + WBV + BZG group.

CONCLUSION:

Either WBV or BZG alone prevents OVX-induced bone loss. However, BZG enhances the effect of WBV by further enhancing BMD, bone architecture and strength.

• Authors: Qiu-shi Wei, Hai-bin Wang, Jun-ling Wang, Bin Fang, Guang-quan Zhou, Xin Tan, Wei He, Wei-min Deng
• Journal: Orthopaedic surgery (Orthop Surg) Vol. 7 Issue 1 Pg. 57-65 (Feb 2015) ISSN: 1757-7861 [Electronic] Australia
• PMID: 25708037 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Chinese Orthopaedic Association and Wiley Publishing Asia Pty Ltd.

Chemical References

• Bone Density Conservation Agents
• Drugs, Chinese Herbal
• bushen zhuanggu

Topics

• Animals
• Bone Density Conservation Agents (therapeutic use)
• Combined Modality Therapy
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Osteoporosis (etiology, prevention & control)
• Ovariectomy
• Postoperative Complications (prevention & control)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Treatment Outcome
• Vibration (therapeutic use)