Corneal plaque containing levofloxacin in a dog.

Abstract

A 13-year-old castrated male Yorkshire terrier developed a corneal ulcer 2 weeks after intracapsular lens extraction (ICLE) in the right eye. The corneal ulcer was treated with levofloxacin eye drops. A plaque with a white luster developed in the central cornea 2 weeks after treatment with levofloxacin eye drops. The corneal plaque was surgically removed under inhalant anesthesia. The corneal plaque displayed antimicrobial activity against Escherichia coli. Furthermore, levofloxacin content in the plaque was confirmed by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS). The corneal ulcer completely resolved 2 weeks after the surgical removal of the corneal lesion and replacement of levofloxacin eye drops with tobramycin eye drops. Although the topical use of levofloxacin is unlikely to lead to corneal chemical deposits due to the high water solubility of the drug compared to other topical fluoroquinolones, this patient developed corneal plaque of the antibiotic drop.

• Authors: Young-Woo Park, Byung-Jae Kang, Jae Hyun Lim, Jung-Mo Ahn, Hyun Sook Lim
• Journal: Veterinary ophthalmology (Vet Ophthalmol) Vol. 18 Issue 6 Pg. 521-6 (Nov 2015) ISSN: 1463-5224 [Electronic] England
• PMID: 25707461 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2015 American College of Veterinary Ophthalmologists.

Chemical References

• Anti-Bacterial Agents
• Levofloxacin

Topics

• Animals
• Anti-Bacterial Agents (adverse effects, analysis, therapeutic use)
• Cornea (chemistry)
• Corneal Diseases (chemically induced, veterinary)
• Corneal Ulcer (drug therapy, veterinary)
• Dog Diseases (chemically induced)
• Dogs
• Female
• Levofloxacin (adverse effects, analysis, therapeutic use)