Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.

Abstract

OBJECTIVES:

The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.

METHODS:

The study population consisted of 972 Caucasian subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 patients with no history of coronary artery disease. Polymorphisms in thioredoxin reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied.

RESULTS:

Individuals carrying CC+CT genotypes of rs1548357 TXNRD2 polymorphism had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, OR=0.589, 95% CI=0.368-0.942, P=0.027).

CONCLUSIONS:

The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for MI in subjects with T2DM of Slovenian origin.

• Authors: Stojan Kariž, Sara Mankoč, Daniel Petrovič
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 108 Issue 2 Pg. 323-8 (May 2015) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 25703281 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• TXNRD2 protein, human
• Thioredoxin Reductase 2

Topics

• Aged
• Diabetes Mellitus, Type 2 (complications, genetics)
• Diabetic Angiopathies (epidemiology, genetics)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Myocardial Infarction (complications, genetics)
• Polymorphism, Single Nucleotide
• Slovenia (epidemiology)
• Thioredoxin Reductase 2 (genetics)
• White People (genetics)