Abstract |
Interleukin-11 (IL-11), a member of the IL-6 family of cytokines, exerts pleiotropic oncogenic activities by stimulating angiogenesis and metastasis in many cancer types. The present study aims to evaluate the impact of IL-11 expression on recurrence and mortality of patients with clear-cell renal cell carcinoma (ccRCC). We retrospectively enrolled 193 ccRCC patients undergoing nephrectomy at a single center. Clinicopathologic features, recurrence-free survival (RFS) and overall survival (OS) were recorded. IL-11 intensity was assessed by immunohistochemistry in tumor specimens. The Kaplan-Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on RFS and OS. The concordance index (C-index) was calculated to assess predictive accuracy. High IL-11 expression is associated with increased risk of recurrence and poor survival for ccRCC patients (P < 0.001 and P < 0.001, respectively), especially those with early-stage disease (TNM stage I + II). Multivariate analyses confirmed that IL-11 expression was an independent prognostic factor for RFS and OS (P = 0.006 and P = 0.008, respectively). The predictive accuracy of well-established prognostic models was improved when IL-11 expression was integrated. In conclusion, high IL-11 expression is an independent predictor of poor prognosis in ccRCC patients. It may help identify patients who could benefit from additional treatments and closer follow up.
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Authors | Deng Pan, Le Xu, Haiou Liu, Weijuan Zhang, Weisi Liu, Yidong Liu, Qiang Fu, Jiejie Xu |
Journal | Cancer science
(Cancer Sci)
Vol. 106
Issue 5
Pg. 592-7
(May 2015)
ISSN: 1349-7006 [Electronic] England |
PMID | 25702890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. |
Chemical References |
- Biomarkers, Tumor
- IL11 protein, human
- Interleukin-11
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Topics |
- Biomarkers, Tumor
(analysis)
- Carcinoma, Renal Cell
(metabolism, mortality, pathology, surgery)
- Cohort Studies
- Female
- Humans
- Interleukin-11
(analysis)
- Kaplan-Meier Estimate
- Kidney Neoplasms
(metabolism, mortality, pathology, surgery)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Nephrectomy
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
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