HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Therapeutic applications of ghrelin agonists in the treatment of gastroparesis.

Abstract
There remains an unmet need for effective pharmacologic treatments for gastroparesis. Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and has been shown to regulate energy homeostasis and exert prokinetic effects on gastrointestinal motility. In recent years, several ghrelin receptor agonists have been studied in clinical trials of patients with diabetic gastroparesis. The intravenous macrocyclic peptidomimetic, TZP-101, initially suggested improvement in gastroparesis symptoms with intravenous administration when compared to placebo. However, in subsequent studies of oral preparations, TZP-102 failed to confirm these results. Another ghrelin receptor agonist, RM-131, was recently shown to significantly accelerate gastric emptying (GE) in patients with type 1 and type 2 diabetes and delayed GE. RM-131 reduced total Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) and composite scores among type 1 diabetics. Continued development of ghrelin agonists should be explored in attempts to expand therapeutic options for the treatment of gastroparesis.
AuthorsAndrea Shin, John M Wo
JournalCurrent gastroenterology reports (Curr Gastroenterol Rep) Vol. 17 Issue 2 Pg. 430 (Feb 2015) ISSN: 1534-312X [Electronic] United States
PMID25702264 (Publication Type: Journal Article, Review)
Chemical References
  • Ghrelin
  • Macrocyclic Compounds
  • Oligopeptides
  • Receptors, Ghrelin
  • relamorelin
  • ulimorelin
Topics
  • Gastrointestinal Motility (drug effects)
  • Gastroparesis (drug therapy, metabolism)
  • Ghrelin (agonists, metabolism)
  • Humans
  • Macrocyclic Compounds (therapeutic use)
  • Oligopeptides (therapeutic use)
  • Receptors, Ghrelin (agonists)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: