Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats.

Abstract

Uveitis is a sight-threatening inflammatory disease of the eye which represents the third leading cause of blindness in the developed countries. The conventional pharmacological treatment includes corticosteroids and immunosuppressive agents, which are limited by their side effects. New therapeutic strategies are thus strongly needed. Exogenously-administered carbon monoxide (CO) may represent an effective treatment for conditions characterized by a dysregulated inflammatory response. Carbon monoxide-releasing molecules (CORMs) are a novel group of compounds capable of carrying and liberating controlled quantities of CO. Among CORMs, CORM-A1 represents the first example of water soluble CO releaser. We show here that CORM-A1 under a late prophylactic regime is able to significantly ameliorate the natural course of experimental autoimmune uveoretinitis, a rodent model of immunoinflammatory posterior uveitis. The present study strongly supports the development of CORM-A1 as a potential new drug for treatment of patients with non-infectious posterior uveitis.

• Authors: Paolo Fagone, Katia Mangano, Santa Mammana, Eugenio Cavalli, Roberto Di Marco, Maria Luisa Barcellona, Lucia Salvatorelli, Gaetano Magro, Ferdinando Nicoletti
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 157 Issue 2 Pg. 198-204 (Apr 2015) ISSN: 1521-7035 [Electronic] United States
• PMID: 25701800 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Boranes
• Carbonates
• Cytokines
• Peptide Fragments
• RNA, Messenger
• Retinol-Binding Proteins
• immunodominant R16 protein, rat
• sodium boranocarbonate

Topics

• Animals
• Autoimmune Diseases (chemically induced, immunology, pathology)
• Boranes (pharmacology)
• Carbonates (pharmacology)
• Cytokines (drug effects, genetics, metabolism)
• Disease Models, Animal
• Female
• Gene Expression (drug effects)
• Peptide Fragments (toxicity)
• RNA, Messenger (drug effects, metabolism)
• Rats
• Rats, Inbred Lew
• Retina (drug effects, immunology, pathology)
• Retinitis (chemically induced, immunology, pathology)
• Retinol-Binding Proteins (toxicity)
• Spleen (drug effects, metabolism)
• T-Lymphocytes, Regulatory (drug effects, immunology)
• Uvea (drug effects, immunology, pathology)
• Uveitis (chemically induced, immunology, pathology)