The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma.

Abstract

Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.

• Authors: Tejashree Karnik, Michael G Ozawa, Martina Lefterova, Sandra Luna-Fineman, Elysia Alvarez, Michael Link, James L Zehnder, Daniel A Arber, Robert S Ohgami
• Journal: Human pathology (Hum Pathol) Vol. 46 Issue 4 Pg. 629-33 (Apr 2015) ISSN: 1532-8392 [Electronic] United States
• PMID: 25701230 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• Biomarkers, Tumor
• GCSAM protein, human
• Immunoglobulin M
• Intracellular Signaling Peptides and Proteins
• LIM Domain Proteins
• LMO2 protein, human
• Microfilament Proteins
• Neoplasm Proteins
• Proto-Oncogene Proteins
• Receptors, Complement 3d

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• B-Lymphocytes (pathology)
• Biomarkers, Tumor (metabolism)
• Child
• Germinal Center (pathology)
• Humans
• Immunoglobulin M (immunology, metabolism)
• Intracellular Signaling Peptides and Proteins
• LIM Domain Proteins (metabolism)
• Lymphoma, Follicular (diagnosis, metabolism)
• Male
• Microfilament Proteins
• Neoplasm Proteins (metabolism)
• Proto-Oncogene Proteins (metabolism)
• Receptors, Complement 3d (metabolism)