Abstract | BACKGROUND: METHODS: A total of 102 patients undergoing valvular heart surgery (from October 2010 to June 2011) were divided into DDAVP group (n = 52) and control group (n = 50). A dose of DDAVP (0.3 μg/kg) was administered to the patients intravenously when they were being re-warmed. At the same time, an equal volume of saline was given to the patients in the control group. PLT aggregation rate was measured with the AggRAM four-way PLT aggregation measurement instrument. The blood loss and transfusion, hemoglobin levels, PLT counts, and urine outputs at different time were recorded and compared. RESULTS: The postoperative blood loss in the first 6 h was significantly reduced in DDAVP group (202 ± 119 ml vs. 258 ± 143 ml, P = 0.023). The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in DDAVP group (3.8% vs. 12%, P = 0.015). There was no significant difference in the PLT aggregation, urine volumes, red blood cell transfusions and blood loss after 24 h between two groups. CONCLUSIONS: A single dose of DDAVP can reduce the first 6 h blood loss and FFP transfusion postoperatively in patients undergoing valvular heart surgery, but has no effect on PLT aggregation.
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Authors | Lei Jin, Hong-Wen Ji |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 128
Issue 5
Pg. 644-7
(Mar 05 2015)
ISSN: 2542-5641 [Electronic] China |
PMID | 25698197
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Deamino Arginine Vasopressin
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Topics |
- Adult
- Cardiac Surgical Procedures
(methods)
- Deamino Arginine Vasopressin
(administration & dosage, therapeutic use)
- Female
- Hemorrhage
(drug therapy)
- Humans
- Male
- Middle Aged
- Platelet Aggregation
(drug effects)
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