Effects of norakin on respiratory syncytial virus in tissue culture and in mice.

Abstract

Norakin at 1 microgram/ml inhibits the reproduction of respiratory syncytial virus (RSV) in Vero cells to 50% and at 5 micrograms/ml to 90%. The development of lung lesions in RSV-infected BALB/c mice was suppressed by 70% when the animals were treated with two doses (25 mg/kg each) of norakin, 30 min before and 4 hr post infection. (p.i.), respectively.

• Authors: R Mentel, C Schroeder, L Döhner
• Journal: Acta virologica (Acta Virol) Vol. 33 Issue 2 Pg. 162-6 (Mar 1989) ISSN: 0001-723X [Print] Slovakia
• PMID: 2569812 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Piperidines
• triperiden

Topics

• Animals
• Antiviral Agents (pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Mice
• Mice, Inbred BALB C
• Piperidines (pharmacology, therapeutic use)
• Pneumonia, Viral (drug therapy)
• Respiratory Syncytial Viruses (drug effects, physiology)
• Respirovirus Infections (drug therapy)
• Vero Cells
• Virus Replication (drug effects)