NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.

Abstract

In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.

• Authors: S F Stasheff, W W Anderson, S Clark, W A Wilson
• Journal: Science (New York, N.Y.) (Science) Vol. 245 Issue 4918 Pg. 648-51 (Aug 11 1989) ISSN: 0036-8075 [Print] United States
• PMID: 2569762 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• Dibenzocycloheptenes
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter
• Aspartic Acid
• N-Methylaspartate
• Dizocilpine Maleate
• 2-Amino-5-phosphonovalerate
• Valine

Topics

• 2-Amino-5-phosphonovalerate
• Animals
• Anticonvulsants (pharmacology)
• Aspartic Acid (analogs & derivatives, antagonists & inhibitors)
• Dibenzocycloheptenes (pharmacology)
• Disease Models, Animal
• Dizocilpine Maleate
• Electric Stimulation
• Electrophysiology
• Epilepsy (physiopathology)
• Evoked Potentials
• Hippocampus (physiopathology)
• In Vitro Techniques
• N-Methylaspartate
• Rats
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter (physiology)
• Seizures (physiopathology)
• Valine (analogs & derivatives, pharmacology)