Hemorrhagic complications associated with PR3-ANCA crescentic glomerulonephritis.

Abstract

Hemorrhagic complications of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis are life-threatening conditions. Of these, alveolar hemorrhage is the most common and well-described hemorrhagic complication and is a prominent component of the pulmonary-renal syndrome. The clinical presentation of alveolar hemorrhage is highly variable ranging from mild to serious disease that may require respiratory support. Less attention has been directed at hemorrhagic complications that have been reported in other organs and which may be as severe or more severe with regard to morbidity and mortality. For example, among the most serious non-pulmonary complications are those related to cerebral and gastrointestinal hemorrhage. Cerebral hemorrhage is the clearly the most critical issue with a persistent high mortality rate. The prognosis of gastrointestinal hemorrhage, once an ominous complication has improved with medical and surgical intervention. Not to be dismissed are the consequences of hemorrhagic issues related to skin, soft tissue or muscle involvement. Muscle hematomas, while rare, also accompanied by significant morbidity.

• Authors: Yali Cao, Zhigang Tian, Wenge Li, Yanfang Yang, Guochun Wang
• Journal: Renal failure (Ren Fail) Vol. 37 Issue 5 Pg. 745-50 (Jun 2015) ISSN: 1525-6049 [Electronic] England
• PMID: 25697228 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Immunosuppressive Agents
• Cyclophosphamide
• Azathioprine

Topics

• Aged
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (complications)
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Azathioprine (therapeutic use)
• Biopsy
• Cyclophosphamide (therapeutic use)
• Female
• Gastrointestinal Hemorrhage
• Glomerulonephritis (diagnosis)
• Glomerulonephritis, Membranoproliferative (complications, drug therapy, pathology)
• Hemorrhage (diagnosis)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Lung Diseases (diagnosis)
• Tomography, X-Ray Computed