Abstract |
Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inflammatory diseases. Circulating levels of EMPs are thought to reflect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be defined in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk stratification models.
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Authors | Alexander Berezin, Anthony Zulli, Steve Kerrigan, Daniel Petrovic, Peter Kruzliak |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 48
Issue 9
Pg. 562-8
(Jun 2015)
ISSN: 1873-2933 [Electronic] United States |
PMID | 25697107
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Biomarkers
- Cardiovascular Diseases
(blood, diagnosis, epidemiology)
- Cell-Derived Microparticles
(physiology)
- Diabetes Mellitus
(blood)
- Endothelium, Vascular
(physiology)
- Humans
- Kidney Failure, Chronic
(blood)
- Metabolic Syndrome
(blood)
- Risk Assessment
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