[Opioids--triggers of adaptive phenomenon of ischemic preconditioning of heart].

Abstract

It was established that short-term ischemia/reperfusion evokes an increase in myocardial tissue of enkephalin levels. A blockade of delta-opioid receptors abolishes the cardioprotective effect of ischemic preconditioning both in vivo and in vitro. An inhibition of kappa-opioid receptors abolishes the cardioprotective effect of ischemic preconditioning only in vitro. Agonists of mu-, delta1- delta- and kappa1-opioid receptors mimic the cardioprotective effect of preconditioning. Consequently, it can be argued that endogenous opioid peptides are triggers of ischemic preconditioning.

• Authors: L N Maslov, N V Naryzhnaia, Iu K Podoksenov, A G Mrochek, A S Gorbunov, S Iu Tsibul'nikov
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 100 Issue 9 Pg. 993-1007 (Sep 2014) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 25697009 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Opioid Peptides
• Receptors, Opioid

Topics

• Adaptation, Physiological
• Animals
• Humans
• Ischemic Preconditioning, Myocardial
• Myocardium (metabolism)
• Opioid Peptides (metabolism)
• Receptors, Opioid (agonists, metabolism)