Fibroblast growth factor 23 predicts coronary calcification and poor prognosis in patients with chronic kidney disease stages 3-5D.

Abstract

OBJECTIVE:

To investigate the relationship of fibroblast growth factor-23 (FGF23) to coronary calcification and prognosis in patients with chronic kidney disease (CKD) stages 3-5D.

METHOD:

We determined serum levels of intact FGF23 in 150 patients with CKD stages 3-5D, using an enzyme-linked immunosorbent assay (ELISA). The coronary calcification was detected with multi-slice CT, and its relationship to FGF23 was analyzed. These patients were followed up over a period of 35±3 months.

RESULT:

Serum FGF23 levels of patients with CKD stages 3-5D were significantly higher than those of the healthy control group (p<0.01). There was a significant positive correlation between serum FGF23 levels and coronary calcification score (CaS) (r=0.177, p<0.05). Age, dialysis vintage, and FGF23 levels were independent risk factors for coronary calcification in patients with CKD stages 3-5D. Receiver-operating characteristic (ROC) curves showed that the sensitivity and specificity of FGF23 were 62.5% and 75.9%, respectively, for diagnosing coronary calcification, with an area of 0.705 under the curve (p<0.01). Kaplan-Meier analysis revealed that survival rates were significantly better in patients with lower FGF23 levels (p<0.05). In Cox regression analysis, FGF23 levels and severe coronary calcification (CaS>400) were independent risk factors for all-cause mortality.

CONCLUSION:

Serum FGF23 level in patients with CKD stages 3-5D was significantly higher than in the healthy controls. These increased FGF23 levels are likely associated with coronary calcification and poor prognosis.

• Authors: Minfang Zhang, Jiayi Yan, Mingli Zhu, Zhaohui Ni
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 45 Issue 1 Pg. 17-22 ( 2015) ISSN: 1550-8080 [Electronic] United States
• PMID: 25696005 (Publication Type: Journal Article)
• Copyright: © 2015 by the Association of Clinical Scientists, Inc.

Chemical References

• FGF23 protein, human
• Fibroblast Growth Factors
• Fibroblast Growth Factor-23

Topics

• Calcinosis (blood, complications)
• Cardiomyopathies
• Female
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors (blood)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Prognosis
• ROC Curve
• Renal Insufficiency, Chronic (blood, complications, pathology)