Abstract | BACKGROUND: METHODS: Patients were identified in the Norwegian Kidney Biopsy Registry. We included all patients with pauci-immune crescentic glomerulonephritis and a positive ANCA test from 1988 to 2012. Deaths and ESRD in the cohort were identified through record linkage with the Norwegian Population Registry (deaths) and the Norwegian Renal Registry ( ESRD). Outcomes of patients diagnosed in 1988-2002 were compared with outcomes of patients diagnosed in 2003-12. RESULTS: A cohort of 455 patients with ANCA-associated glomerulonephritis was identified. The mean follow-up was 6.0 years (range, 0.0-23.4). During the study period, 165 (36%) patients died and 124 (27%) progressed to ESRD. Compared with patients diagnosed in 1988-2002, those diagnosed in 2003-12 had higher mean initial estimated glomerular filtration rates (37 versus 27 mL/min/1.73 m(2)) and lower risk of ESRD (1-year risk: 13 versus 19%; 10-year risk: 26 versus 37%). The composite endpoint, ESRD or death within 0-1 year after diagnosis, was reduced from 34 to 25%. In patients over 60 years old, 1-year mortality fell from 33 to 20%. CONCLUSIONS: In Norwegian patients with ANCA-associated glomerulonephritis, prognosis was significantly better in 2003-12 compared with 1988-2002. This improvement was probably partly due to a shorter diagnostic delay, and better therapeutic management in older patients.
|
Authors | Sanjeevan Sriskandarajah, Knut Aasarød, Steinar Skrede, Thomas Knoop, Anna Varberg Reisæter, Rune Bjørneklett |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 30 Suppl 1
Pg. i67-75
(Apr 2015)
ISSN: 1460-2385 [Electronic] England |
PMID | 25694535
(Publication Type: Journal Article)
|
Copyright | © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. |
Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
|
Topics |
- Adult
- Aged
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
(complications, diagnosis, mortality)
- Antibodies, Antineutrophil Cytoplasmic
(blood)
- Female
- Glomerulonephritis
(diagnosis, etiology, mortality)
- Humans
- Male
- Middle Aged
- Norway
- Prognosis
- Survival Rate
- Young Adult
|