The quinoxalinediones antagonise the visual firing of sustained retinal ganglion cells.

Abstract

The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) has no effect. Thus, the endogenous excitatory amino acid released onto these cells on visual stimulation acts at non-NMDA receptors.

• Authors: C D Kay, H Ikeda
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 164 Issue 2 Pg. 381-4 (May 19 1989) ISSN: 0014-2999 [Print] Netherlands
• PMID: 2569410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Piperazines
• Quinoxalines
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter
• FG 9041
• 6-Cyano-7-nitroquinoxaline-2,3-dione
• 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

Topics

• 6-Cyano-7-nitroquinoxaline-2,3-dione
• Animals
• Cats
• In Vitro Techniques
• Iontophoresis
• Piperazines (pharmacology)
• Quinoxalines (pharmacology)
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter (drug effects)
• Retina (drug effects)
• Retinal Ganglion Cells (drug effects, physiology)