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[Causal relationship between the use of gadolinium based contrast media and nephrogenic systemic fibrosis].

Abstract
Nephrogenic systemic fibrosis (NSF) is a severe iatrogenic disease that affect patients with impaired renal function exposed to gadolinium-based contrast agents. Clinically, symptoms develop within days or weeks after the exposure and mimic a scleromyxedema. The causal relationship between use of gadolinium-based contrast agents and NSF led to develop clinical guidelines aiming to limit the use of this contrast medium in high risk patients. These guidelines decreased the incidence of NSF in the last years. Unfortunately there is no specific treatment for NSF yet. Thus, strict adherence to current guidelines is key to prevent new cases. Renal dysfunction is increasingly common in our population. Therefore, practicing physicians should be aware of this potential complication of the use of gadolinium based contrast media.
AuthorsCristian U Varela, Juan Carlos Prieto-Rayo
JournalRevista medica de Chile (Rev Med Chil) Vol. 142 Issue 12 Pg. 1565-74 (Dec 2014) ISSN: 0717-6163 [Electronic] Chile
Vernacular TitleFibrosis sistémica nefrogénica: la pandemia que no fue.
PMID25693439 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Contrast Media
  • Gadolinium
Topics
  • Contrast Media (adverse effects)
  • Gadolinium (adverse effects)
  • Humans
  • Nephrogenic Fibrosing Dermopathy (chemically induced, diagnosis, prevention & control)
  • Risk Factors

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