HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites.

Abstract
A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB). The CQ resistance-reversing activity of 2-APB, which showed the same efficacy as verapamil, was also observed in an in vivo mouse infection model with the CQ-resistant Plasmodium chabaudi AS(30CQ) strain.
AuthorsEhab Mossaad, Wakako Furuyama, Masahiro Enomoto, Satoru Kawai, Katsuhiko Mikoshiba, Shin-ichiro Kawazu
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 5 Pg. 2890-2 (May 2015) ISSN: 1098-6596 [Electronic] United States
PMID25691631 (Publication Type: Journal Article)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Chemical References
  • Antimalarials
  • Chloroquine
  • Verapamil
Topics
  • Animals
  • Antimalarials (therapeutic use)
  • Chloroquine (therapeutic use)
  • Female
  • Inhibitory Concentration 50
  • Malaria (drug therapy, parasitology)
  • Mice
  • Mice, Inbred ICR
  • Plasmodium falciparum (drug effects, pathogenicity)
  • Verapamil (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: