Abstract |
A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB). The CQ resistance-reversing activity of 2-APB, which showed the same efficacy as verapamil, was also observed in an in vivo mouse infection model with the CQ-resistant Plasmodium chabaudi AS(30CQ) strain.
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Authors | Ehab Mossaad, Wakako Furuyama, Masahiro Enomoto, Satoru Kawai, Katsuhiko Mikoshiba, Shin-ichiro Kawazu |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 59
Issue 5
Pg. 2890-2
(May 2015)
ISSN: 1098-6596 [Electronic] United States |
PMID | 25691631
(Publication Type: Journal Article)
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Copyright | Copyright © 2015, American Society for Microbiology. All Rights Reserved. |
Chemical References |
- Antimalarials
- Chloroquine
- Verapamil
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Topics |
- Animals
- Antimalarials
(therapeutic use)
- Chloroquine
(therapeutic use)
- Female
- Inhibitory Concentration 50
- Malaria
(drug therapy, parasitology)
- Mice
- Mice, Inbred ICR
- Plasmodium falciparum
(drug effects, pathogenicity)
- Verapamil
(therapeutic use)
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