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Esophageal and esophagogastric junction cancers, version 1.2015.

Abstract
Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ.
AuthorsJaffer A Ajani, Thomas A D'Amico, Khaldoun Almhanna, David J Bentrem, Stephen Besh, Joseph Chao, Prajnan Das, Crystal Denlinger, Paul Fanta, Charles S Fuchs, Hans Gerdes, Robert E Glasgow, James A Hayman, Steven Hochwald, Wayne L Hofstetter, David H Ilson, Dawn Jaroszewski, Kory Jasperson, Rajesh N Keswani, Lawrence R Kleinberg, W Michael Korn, Stephen Leong, A Craig Lockhart, Mary F Mulcahy, Mark B Orringer, James A Posey, George A Poultsides, Aaron R Sasson, Walter J Scott, Vivian E Strong, Thomas K Varghese Jr, Mary Kay Washington, Christopher G Willett, Cameron D Wright, Debra Zelman, Nicole McMillian, Hema Sundar, National comprehensive cancer network
JournalJournal of the National Comprehensive Cancer Network : JNCCN (J Natl Compr Canc Netw) Vol. 13 Issue 2 Pg. 194-227 (Feb 2015) ISSN: 1540-1413 [Electronic] United States
PMID25691612 (Publication Type: Journal Article, Practice Guideline)
CopyrightCopyright © 2015 by the National Comprehensive Cancer Network.
Topics
  • Esophageal Neoplasms (diagnosis, therapy)
  • Esophagogastric Junction (pathology)
  • Humans
  • Stomach Neoplasms (diagnosis, therapy)

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