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Nuclear pore proteins and the control of genome functions.

Abstract
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.
AuthorsArkaitz Ibarra, Martin W Hetzer
JournalGenes & development (Genes Dev) Vol. 29 Issue 4 Pg. 337-49 (Feb 15 2015) ISSN: 1549-5477 [Electronic] United States
PMID25691464 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Copyright© 2015 Ibarra and Hetzer; Published by Cold Spring Harbor Laboratory Press.
Chemical References
  • Nuclear Pore Complex Proteins
Topics
  • Animals
  • Chromosome Duplication (genetics)
  • Chromosome Segregation (genetics)
  • Gene Expression Regulation
  • Genome
  • Genomic Instability
  • Humans
  • Nuclear Pore Complex Proteins (genetics, metabolism)

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