Abstract |
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.
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Authors | Arkaitz Ibarra, Martin W Hetzer |
Journal | Genes & development
(Genes Dev)
Vol. 29
Issue 4
Pg. 337-49
(Feb 15 2015)
ISSN: 1549-5477 [Electronic] United States |
PMID | 25691464
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2015 Ibarra and Hetzer; Published by Cold Spring Harbor Laboratory Press. |
Chemical References |
- Nuclear Pore Complex Proteins
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Topics |
- Animals
- Chromosome Duplication
(genetics)
- Chromosome Segregation
(genetics)
- Gene Expression Regulation
- Genome
- Genomic Instability
- Humans
- Nuclear Pore Complex Proteins
(genetics, metabolism)
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