Metaplastic breast cancer: clinical overview and molecular aberrations for potential targeted therapy.

Abstract	Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.
Authors	Sausan Abouharb, Stacy Moulder
Journal	Current oncology reports (Curr Oncol Rep) Vol. 17 Issue 3 Pg. 431 (Mar 2015) ISSN: 1534-6269 [Electronic] United States
PMID	25691085 (Publication Type: Journal Article, Review)
Chemical References	Antineoplastic Agents
Topics	Antineoplastic Agents (therapeutic use) Breast Neoplasms (drug therapy, genetics, pathology, secondary) Carcinoma (drug therapy, genetics, pathology, secondary) Diagnosis, Differential Female Humans Molecular Targeted Therapy (methods) Prognosis Rare Diseases (drug therapy, genetics, pathology)

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