Current status of photodynamic therapy in digestive tract carcinoma in Japan.

Abstract

Photodynamic therapy (PDT) is an effective local treatment modality as a cancer-specific laser ablation in malignancy of some organs including digestive tracts or bile duct. In Japan, PDT has been applied at the early period after the first clinical induction in 1980's. Although the useful efficacy was clarified, PDT has not been fully applied because of the phototoxicity of the porfimer sodium. The next generated talaporfin-sodium was used for PDT, in which phototoxicity was reduced and, however, the clinical efficacy for digestive tract malignancy has not yet been clarified. By proceeding the experimental and clinical trials, it is necessary to clarify the evidence of efficacy as a local powerful treatment with the conventional surgery, brachiotherapy and chemotherapy in the future step.

• Authors: Atsushi Nanashima, Takeshi Nagayasu
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 2 Pg. 3434-40 (Feb 04 2015) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 25690028 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Porphyrins
• Dihematoporphyrin Ether
• Talaporfin

Topics

• Carcinoma (drug therapy)
• Dihematoporphyrin Ether (therapeutic use)
• Endoscopy, Gastrointestinal
• Gastrointestinal Neoplasms (drug therapy)
• Humans
• Japan
• Lasers
• Photochemotherapy (trends)
• Photosensitizing Agents (therapeutic use)
• Porphyrins (therapeutic use)