The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer.

Abstract

The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy.

• Authors: Chun-Yuan Chang, Jyh-Der Leu, Yi-Jang Lee
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 2 Pg. 4095-120 (Feb 13 2015) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 25689427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Actin Depolymerizing Factors
• Actins
• Ataxia Telangiectasia Mutated Proteins

Topics

• Actin Cytoskeleton
• Actin Depolymerizing Factors (metabolism)
• Actins (metabolism)
• Ataxia Telangiectasia Mutated Proteins (metabolism)
• DNA Repair
• Humans
• Neoplasms (metabolism, pathology, radiotherapy)
• Radiation, Ionizing
• Signal Transduction