Inherited
factor VII (FVII) deficiency is a rare autosomal recessive
hemorrhagic disorder. The major clinical symptoms include:
bleeding from the oral cavity,
epistaxis,
menorrhagia, spontaneous hemarthros,
bleeding to the gastrointestinal tract and central nervous system, and perioperative
bleeding. The aim of this study was to present our experience in preventing
bleeding and
hemorrhagic disorders in surgical patients with inherited FVII deficiency by using recombinant activated FVIIa (
rFVIIa), and with
prothrombin complex concentrates (PCCs). In 2002-2011, 17 patients with inherited FVII deficiency underwent surgery. Thirteen patients had isolated FVII deficiency below 10%, and four patients 10-25. To prevent
bleeding and hemorrhagic complications, we administered small single doses of
rFVIIa (
Novo-Seven) at 12-h intervals to 15 patients on
surgery day and on day 1 following surgery, then every 24 h; PCCs were administered (Prothromplex, Beriplex) to two patients. No symptoms of
bleeding, hemorrhagic or thromboembolic complications were observed in the perioperative and 1-month observation period in surgical patients treated with
rFVIIa. One patient treated with PCC (Prothromplex) developed distal
deep vein thrombosis on postoperative day 7. The results suggest that small, single, every 12-h doses of
rFVIIa (
NovoSeven) and in next days after surgery one time every 24 h are well tolerated and effective for prevention of thromboembolic,
bleeding and hemorrhagic complications in FVII-deficient patients. Antithrombotic prophylaxis with
low-molecular-weight heparin should be applied in patients using PCCs.