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Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy.

Abstract
In the past few decades, the in situ sustained drug delivery platforms present fascinating potential in sentinel chemotherapy of various solid tumors. In this work, doxorubicin (DOX), a model antitumor drug, was loaded into the thermogel of poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide). The moderate mechanical property of DOX-loaded hydrogel was confirmed by rheological test. In vitro degradation revealed the good biodegradability of thermogel. The DOX-loaded hydrogel exhibited the sustained release profiles up to 30days without and even with elastase. The improved in vivo tumor inhibition and reduced side-effects were observed in the DOX-incorporated hydrogel group compared with those in free DOX group. The excellent in vivo results were further confirmed by the histopathological evaluation or terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. The thermogel with great prospect may be used as an ideal controlled drug delivery platform for the designated and long-term antitumor chemotherapy.
AuthorsYanbo Zhang, Jianxun Ding, Diankui Sun, Hai Sun, Xiuli Zhuang, Fei Chang, Jincheng Wang, Xuesi Chen
JournalMaterials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 49 Pg. 262-268 (Apr 2015) ISSN: 1873-0191 [Electronic] Netherlands
PMID25686948 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Drug Carriers
  • Polyesters
  • poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • Doxorubicin
  • Pancreatic Elastase
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Delayed-Action Preparations (administration & dosage, chemistry)
  • Doxorubicin (administration & dosage, chemistry)
  • Drug Carriers (administration & dosage, chemistry)
  • Drug Delivery Systems (methods)
  • Hydrogel, Polyethylene Glycol Dimethacrylate (administration & dosage, chemistry)
  • Male
  • Mice
  • Pancreatic Elastase (metabolism)
  • Polyesters (chemistry)
  • Polyethylene Glycols (chemistry)

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