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Effects of indeloxazine hydrochloride on cognitive disturbance in cycloheximide-treated mice.

Abstract
The effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride] on cognitive disturbance in mice subjected to cycloheximide have been examined. Indeloxazine ameliorated cycloheximide-induced amnesia in mice, indicating a facilitatory effect of this drug on cerebral functions. Piracetam, Cahopantenate, dihydroergotoxine and viloxazine did not show significant effect on the amnesia. These results suggest that indeloxazine possesses a wider pharmacological profile than piracetam, Cahopantenate, dihydroergotoxine and viloxazine in anti-amnesic activities.
AuthorsM Yamamoto, M Shimizu
JournalThe Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 41 Issue 4 Pg. 284-6 (Apr 1989) ISSN: 0022-3573 [Print] England
PMID2568476 (Publication Type: Journal Article)
Chemical References
  • Antidepressive Agents
  • Morpholines
  • indeloxazine
  • Cycloheximide
Topics
  • Animals
  • Antidepressive Agents (pharmacology)
  • Avoidance Learning (drug effects)
  • Cognition Disorders (chemically induced, drug therapy)
  • Cycloheximide
  • Male
  • Memory (drug effects)
  • Mice
  • Mice, Inbred ICR
  • Morpholines (pharmacology)
  • Motor Activity (drug effects)

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