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[Tasquinimod: How to act on microenvironment in metastatic prostate cancer].

Abstract
Despite the recent introduction of new drugs, castration-resistant metastatic prostate cancer, (mCRPC) remains a poor prognosis disease, with a crucial need for new therapeutic approaches. Tasquinimod is a newly developed molecule, orally administered, currently evaluated in phase III studies. Tasquinimod targets the tumor microenvironment, focusing on the angiogenic and immune components. Its specific action on the S100A9 protein restores immunity and reduces angiogenesis. A phase II double-blind randomized study against placebo showed an improvement of more than 50% of progression free survival in the group of mCRPC patients treated with tasquinimod, as compared to the placebo group. At a dose of 1mg/day, the tolerance of tasquinimod appeared acceptable. This review presents the available preclinical and clinical results of tasquinimod, with a particular focus on the originality of its mode of action.
AuthorsN Houédé, J Irani
JournalProgres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (Prog Urol) Vol. 25 Issue 6 Pg. 298-305 (May 2015) ISSN: 1166-7087 [Print] France
Vernacular TitleTasquinimod: ou comment agir sur le microenvironnement dans le cancer métastatique de la prostate.
PMID25684391 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2015 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Quinolines
  • Quinolones
  • tasquinimod
Topics
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant (drug therapy, secondary)
  • Quinolines (pharmacology, therapeutic use)
  • Quinolones
  • Tumor Microenvironment (drug effects)

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