Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage.

Abstract

This study describes an interesting observation that the mixture of anomeric galactolipids has synergistic effects on the growth inhibition of human multiple myeloma (MM) cells. We determine that the equivalent mixture of a pair of α- and β-galactolipids with a 14-carbon lipid chain can cause stronger poly ADP-ribose polymerase cleavage and DNA damage, producing more late apoptotic MM cells, than either anomer alone.

• Authors: Si-Si Deng, Chao Zhang, Huan Wang, Yi Zang, Jia Li, Xiao-Peng He, Guo-Rong Chen
• Journal: Carbohydrate research (Carbohydr Res) Vol. 408 Pg. 114-8 (May 18 2015) ISSN: 1873-426X [Electronic] Netherlands
• PMID: 25683967 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Galactolipids
• Poly(ADP-ribose) Polymerases

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Apoptosis
• Cell Line, Tumor
• Cell Survival (drug effects)
• DNA Damage
• Drug Synergism
• Galactolipids (chemistry, pharmacology)
• Humans
• Multiple Myeloma (genetics)
• Poly(ADP-ribose) Polymerases (metabolism)