Reversible Splenial Lesion Syndrome (RESLES) Following Glufosinate Ammonium Poisoning.

Abstract

Isolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high-altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39-year-old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion-weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow-up MR imaging performed 9 months later. We postulate that a GLA-induced excitotoxic mechanism was the cause of this reversible splenial lesion.

• Authors: Tae Oh Jeong, Jae Chol Yoon, Jae Baek Lee, Young Ho Jin, Seung Bae Hwang
• Journal: Journal of neuroimaging : official journal of the American Society of Neuroimaging (J Neuroimaging) 2015 Nov-Dec Vol. 25 Issue 6 Pg. 1050-2 ISSN: 1552-6569 [Electronic] United States
• PMID: 25682793 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 by the American Society of Neuroimaging.

Chemical References

• Aminobutyrates
• phosphinothricin

Topics

• Adult
• Aminobutyrates (poisoning)
• Brain Edema (chemically induced, diagnostic imaging)
• Corpus Callosum (diagnostic imaging, drug effects)
• Diffusion Magnetic Resonance Imaging
• Female
• Humans
• Remission, Spontaneous
• Seizures (chemically induced, diagnostic imaging)