[Effect of quinpirole on the retrieval of a memory trace in amnesia].

Abstract

In experimental studies on mice it was shown that quinpirole, a selective agonist of dopaminergic postsynaptic D-2 receptors, possessed a pronounced antiamnestic activity. Administration of quinpirole before testing on 2nd and 22nd days reactivated the retrieval of passive avoidance impaired by an amnestic agent. The drug effect depended on the duration of "psychogenic" amnesia. It is suggested that the postsynaptic dopaminergic D-2 receptors are actively involved in the neurochemical mechanisms of memory trace retrieval.

• Authors: R Iu Il'iuchenok, N I Dubrovina, R I Parkhomenko
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1989 Mar-Apr Vol. 52 Issue 2 Pg. 24-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie kvinpirola na vosproizvedenie sleda pamiati pri amnezii.
• PMID: 2568271 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Dopamine Agents
• Ergolines
• Quinpirole

Topics

• Amnesia (drug therapy)
• Animals
• Conditioning, Classical (drug effects)
• Dopamine Agents (therapeutic use)
• Drug Evaluation, Preclinical
• Ergolines (therapeutic use)
• Escape Reaction (drug effects)
• Male
• Memory (drug effects)
• Mice
• Mice, Inbred BALB C
• Quinpirole
• Reaction Time (drug effects)
• Time Factors