Intracameral interleukin 1β, 6, 8, 10, 12p, tumor necrosis factor α and vascular endothelial growth factor and axial length in patients with cataract.

Abstract

OBJECTIVE:

To assess associations between the aqueous humour concentration of interleukin IL-1β, IL-6, IL-8, IL-10 and IL-12p, tumor necrosis factor α (TNF-α) and vascular endothelial growth factor (VEGF) and axial length in eyes with cataract.

METHODS:

The hospital-based investigation included patients who underwent cataract surgery between March 2014 and April 2014. Using aqueous humour collected at the start of cataract surgery, the interleukins IL-1β, IL-6, IL-8, IL-10 and IL-12p, TNF-α and VEGF were examined using a cytometric bead array. Axial length was determined by partial coherence laser interferometry (IOL Master).

RESULTS:

The study included 33 patients with cataract (33 eyes) with a mean age of 69.2±10.8 years (range: 50-87 years) and a mean axial length of 24.7±1.9 mm (range: 22.6-31.5 mm). Lower aqueous concentration of VEGF was significantly associated with longer axial length (VEGF concentration (pg/mL) = -5.12 x Axial Length (mm) + 163; correlation coefficient r = -0.41; P<0.001) and more myopic refractive error (VEGF concentration (pg/mL) = 1.27 x spherical equivalent (diopters) + 44.8; r = 0.383; P = 0.002). The aqueous concentrations of all other substances were not significantly (all P>0.10) associated with axial length or refractive error.

CONCLUSIONS:

Higher intravitreal concentrations of VEGF were measured in eyes with a longer axial length, while the intraocular concentrations of IL-1β, IL-6, IL-8, IL-10, IL-12p and TNF-α were not correlated with axial length. The lower concentration of VEGF in axially elongated eyes may be one of the reasons for the lower prevalence of age-related macular degeneration and diabetic retinopathy in myopic eyes.

• Authors: Dan Zhu, Da-Yong Yang, Yuan-Yuan Guo, Yan-Fei Zheng, Jun-Lian Li, Bin Wang, Yong Tao, Jost B Jonas
• Journal: PloS one (PLoS One) Vol. 10 Issue 2 Pg. e0117777 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25679504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cytokines

Topics

• Aged
• Aged, 80 and over
• Aqueous Humor (metabolism)
• Biomarkers
• Cataract (diagnosis, metabolism, pathology, therapy)
• Cataract Extraction
• Cytokines (metabolism)
• Female
• Humans
• Male
• Middle Aged